Lori is a young woman who leads her own gang of delinquents and all of whom attends Meridiana High School where they are taught by Adrian Seidelman and Lucas Amato in literature and science, respectively.
She has a crush on Adrian and despite her childish and mean personality, grows to develop a sense of maturity and later treats her teachers more respectfully.
Lori grew up travelling around with the circus as her home with her younger brother, Antonio Cadenas, where the two were taught acrobatic skills by their father. It's unknown where their Lori's parents currently are. There was also a bad experience with a clown that left Lori traumatized and not wanting this to happen to other children motivates her to rescue Ikiko Yashimoto later on in life. At some point she left the circus life to stay in the city of Meridiana for what her brother says is for the rock bands and drugs, and when she visits her brother, she expresses a wish to return but she disliked touring and living in tents and caravans and also found a new interest in Adrian.
Shortly after Lucas is hired as the new biology teacher, Lori makes a suggestive offering to Adrian but he rejects it, leading to her using her gang to attempt to beat him up only to be interrupted by Lucas and the police. Afterwards, she bullies Adrian and eventually causes a rift between him and Lucas when she accuses Cybersix of playing them both, leading to an odd love triangle as unbeknownst to everyone else, Adrian and Cybersix are actually the same person. Lori is mean and promiscuous but is also shown as being occasionally nice, apologetic, remorseful of her actions and compassionate.
In the end, Lori accompanies Cybersix to Von Reichter's base to rescue Gengis but the building is shown to be destroyed by fire. After a defected minion returns Gengis to Cybersix and Lucas, Lori appears shocked about Adrian, and possibly learns in that moment of Cybersix's secret identity.
Lori is first seen trying to seduce Adrian in class, and when he refuses, she hides out in an abandoned building and waits for one of her gangsters to lure Adrian there. She then attempts to seduce him again but is interrupted when Lucas runs into the building and punches one of her men. When another one of her gangsters pulls a knife, Lori orders a retreat and they all run away.
That night, Lori watches Adrian's apartment with binoculars and sees Cybersix enter through the window, dressing into Adrian's clothes. Fuming with jealousy, she runs off and tells her friends and also to Lucas the next morning at his office. When Lori appears next in class, she's wearing a black hat and cape. Angry, Adrian pulls her away outside for a talk but is interrupted when Lucas approaches, pushes Lori away and acting aggressively for the supposed affair Adrian has with Cybersix.
Lori is a bright young woman who seems to be doing well in school and has a crush on Adrian. Unlike in the comics, she wouldn't directly hurt Adrian although after she finds Adrian's apartment and seeing Cybersix inside, in jealousy she tries to ruin his reputation as a respectable man by telling Lucas what she saw. Her feelings of jealousy are resolved after being rescued by Cybersix from José. Lori's crush on Adrian also becomes less apparent after this but is visibly concerned about him when he becomes injured during a school trip.
Lori's parents are seen in the last episode, showing she has her father's red hair and mother's front hairstyle. No other sibling is seen with them as they evacuate the city so it can be assumed she is a single child.
Lori's last major appearance is in the last episode where Cybersix confronts her with Adrian's eyeglasses, who Lori later gives to Lucas. It's unknown if the two now know Adrian was a disguise for Cybersix due to the ambiguous ending.
Cybersix and Lori Anderson only encountered one and other three times throughout the animated series. When Lori finds out where Adrian lives, she overhears a conversation between Cybersix and Data 7. She spies on them through the peephole and because she couldn't see the latter, Lori naturally assumes that the person she is talking to is Adrian and is obviously hurt, developing a bitter jealousy of Cybersix. Cybersix in turn is pretty indifferent to Lori as she worries about worse things. After Jose kidnaps Lori for stumbling on his Drill Tank plans, Cybersix goes in to rescue her. While still bitter at her, for her supposed involvement with Adrian, Lori helps Cybersix in defeating Jose, by sabotaging his Drill Tank's computer program, prompting him to use it manually. Cybersix, then goes as far as setting the Tank on fire with Jose in it. An actions she normally doesn't do directly, showing that Jose thoroughly angered her for harming one of her students from her civilian identity. The third and final time they meet one and other, is before she confronts Dr. Von Reichter. She let's Lori know that Cybersix and Adrian are one and the same and even let's her keep the glasses from her Adrian persona. This proves that on some level, Cybersix does care about Lori. Lori then goes with Luke to try to find Cybersix, only to see Von Reichter's lab blow up. Lori and Lucas are extremely devastated, because Cybersix may have died in the explosion and unlike Lucas, Lori has no hint that Cybersix may still be alive.
Adrian Seidelman and Lori Anderson have a very complicated relationship. While it's pretty obvious, Lori is infatuated with him, she never pays attention to his class. Implying her attraction is mainly physical. Whilst Adrian doesn't share the same feelings with her and views her as a disruption of his class. Despite that, their relationship does share instances of it being deeper. On the Lori side of things, she is actually hurt when she apparently stumbles upon an alleged affair between him and Cybersix, not even knowing that they are one and the same. She also shows some concern over him after he fell into the water, from an attack by Griselda. Adrian in turn does care about Lori's well-being when he finds out she's missing and in the Cybersix persona, went as far as setting Jose's drill tank on fire with him in it for his role in her kidnapping. He also shows concern for Lori when he finds her semi conscious after an encounter with The Eye. Before Cybersix goes out to confront Dr. Von Reichter, she reveals her dual identity to Lori and gives her Adrian's glasses to remember her by. Although Lori didn't like Cybersix after her first meeting with her, it seemed that she still loves Adrian regardless of who he really is, since she was willing to go with Lucas to help find her. When the lab explodes, Lori is just as devastated as Lucas when she thought Cybersix was dead. To add insult to injury, unlike Lucas, she never got a hint that Cybersix might still be alive.
- Lori's parents are never seen in the comics but in the final episode, a redheaded man and blonde woman can be briefly seen together in the streets where Lori is packing away some things into a car. The same man is seen driving that car with Lori in the backseat. It can be determined that the man and woman are Lori's parents.
- Lori's personality and appearance is much more crude in the comic book series, which is a direct contrast to her animated counterpart.